Transcriptomics

Dataset Information

0

Identification of endothelial genes co-regulated upon endothelial Evi/Wls and Rspo3 deletion


ABSTRACT: Inducible endothelial Rspo3 deletion resulted in perturbed developmental and tumor vascular remodeling. Rspo3-iECKO mice strikingly phenocopied the non-canonical WNT signaling-induced vascular defects of mice deleted for the WNT secretion factor Evi/Wls. An endothelial screen for RSPO3 and EVI/WLS co-regulated genes identified novel target genes, which could be linked to WNT/Ca2+/NFAT signaling. In summary, the study identifies endothelial RSPO3-driven non canonical WNT/Ca2+/NFAT signaling as critical maintenance pathway of the remodeling vasculature.

ORGANISM(S): Mus musculus

PROVIDER: GSE75836 | GEO | 2016/02/03

SECONDARY ACCESSION(S): PRJNA305530

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2013-07-24 | E-MTAB-1613 | biostudies-arrayexpress
2016-03-06 | E-MTAB-3995 | biostudies-arrayexpress
2014-12-10 | E-MTAB-2927 | biostudies-arrayexpress
2018-03-22 | GSE112172 | GEO
| PRJNA305530 | ENA
| PRJEB3970 | ENA
2008-05-29 | GSE11557 | GEO
2022-12-28 | GSE214156 | GEO
2022-09-08 | GSE185354 | GEO
2022-09-08 | GSE185348 | GEO