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RNAseq transcriptomic signature associated depletion of Evi/Wls in epidermal sheets of mice, expression analysis of epidermal sheets of Evi/Wls knockout and wildtype mice

ABSTRACT: Evi/Wls is an essential Wnt secretion factor and important for tissue homeostasis. In the skin Wnt signaling plays an important role in hair follicle formation and maintenance. The aim of the present study is to compare the gene expression profile of Evi/Wls knockout epidermal sheets with wild-type control skin.

INSTRUMENT(S): AB SOLiD 4 System

ORGANISM(S): Mus musculus

SUBMITTER: Grainne Kerr 

PROVIDER: E-MTAB-1613 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis.

Augustin Iris I   Gross Julia J   Baumann Daniel D   Korn Claudia C   Kerr Grainne G   Grigoryan Tamara T   Mauch Cornelia C   Birchmeier Walter W   Boutros Michael M  

The Journal of experimental medicine 20130805 9

Cells of the epidermis renew constantly from germinal layer stem cells. Although epithelial cell differentiation has been studied in great detail and the role of Wnt signaling in this process is well described, the contribution of epidermal Wnt secretion in epithelial cell homeostasis remains poorly understood. To analyze the role of Wnt proteins in this process, we created a conditional knockout allele of the Wnt cargo receptor Evi/Gpr177/Wntless and studied mice that lacked Evi expression in t  ...[more]

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