Transcriptomics

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Disulfiram when combined with copper enhances the therapeutic effects of temozolomide for the treatment of Glioblastoma


ABSTRACT: Dilsulfiram together with Copper shows efficacy against patient derived Brain Tumor Initiating Cells (BTICs) in vitro and sensitizes BTICs to the DNA damaging agent TMZ. In addition, preclinical assessment found that DSF/Cu potentiaties the efficicacy of TMZ in vivo and prolongs survival. We used microarrays to detail the global profile of gene expression underlying DSF/Cu treatment in vitro and in vivo in BTICs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE76146 | GEO | 2016/03/21

SECONDARY ACCESSION(S): PRJNA306429

REPOSITORIES: GEO

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