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α-linolenic acid and long-chain n-3 polyunsaturated fatty acids modulate colitis operating with a different gene set

ABSTRACT: Adult Wistar rats were fed diet enriched with either α-linolenic acid (ALA) or fish oil for 8 (n=10) weeks. Colitis was induced in rats using 5% dextran sulfate sodium for 7 days. The rats were dissected and RNA was isolated from the colon tissues of rats, the samples from 6 rats were pooled and used for the microarray experiments. Global gene expression analysis was done in duplicates in each group and the results were compared to n-6 fatty acid group. α-linolenic acid (ALA) and fish oil rich in eicosapentaenoic acid and docosahexaenoic acid significantly attenuated the symptoms of colitis, compared to n-6 fatty acid group. Gene expression analysis has revealed that there is no common gene signature in the two groups.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE76331 | GEO | 2016/10/12

SECONDARY ACCESSION(S): PRJNA307083

REPOSITORIES: GEO

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Salmon liver proteomics - Preliminary Validation of a High Docosahexaenoic Acid (DHA) and -Linolenic Acid (ALA) Dietary Oil Blend: Tissue Fatty Acid Composition and Liver Proteome Response in Atlantic Salmon (Salmo salar) Smolts

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2018-03-01 | PXD004114 | Pride

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2017-03-04 | E-MTAB-3377 | biostudies-arrayexpress

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2019-05-08 | E-MTAB-7366 | biostudies-arrayexpress

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2019-08-14 | PXD009864 | Pride

Hepatic transcriptome of mice fed high fat diets containing palm or linseed oil

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