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A novel compound that blocks HIV-1 replication inhibits the splicing regulatory function of SRSF10

ABSTRACT: Purpose: We have identified a new compound (1C8) that inhibits HIV-1 replication and that displays very low cellular toxicity. Here, we assess the molecular mechanisms of action of 1C8. Following transcription of the HIV-1 genome, its primary transcript is processed to produce dozens of distinct mRNAs through the alternative use of splice sites. Results: 1C8 decreases the activity of SRSF10, a cellular protein that controls the selection of splice sites in HIV-1 transcripts. 1C8 decreases the phosphorylation of SRSF10, and this change is associated with alterations in the interaction of SRSF10 with HIV-1 transcripts and factors that control splice site selection. Thus, 1C8 represents a novel compound with properties that are potentially useful for treating HIV-1 infection.

ORGANISM(S): Homo sapiens

PROVIDER: GSE76947 | GEO | 2016/12/19

SECONDARY ACCESSION(S): PRJNA309122

REPOSITORIES: GEO

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A novel class of CLK kinases inhibitors that target SRSF10 and promote p53mediated cytotoxicity on human colorectal cancer cells

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2021-09-09 | PXD022333 | Pride

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SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in the developing mouse neocortex

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