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Wnt/β-catenin in Xenopus laevis gastrulation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Xenopus laevis

PROVIDER: GSE77365 | GEO | 2016/04/25

SECONDARY ACCESSION(S): PRJNA310142

REPOSITORIES: GEO

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Wnt/β-catenin in Xenopus laevis gastrulation

Project description:Wnt/β-catenin in Xenopus laevis gastrulation

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Genome-wide identification of Wnt/β-catenin transcriptional targets during Xenopus gastrulation.

Project description:The canonical Wnt/β-catenin signaling pathway plays multiple roles during Xenopus gastrulation, including posteriorization of the neural plate, patterning of the mesoderm, and induction of the neural crest. Wnt signaling stabilizes β-catenin, which then activates target genes. However, few targets of this signaling pathway that mediate early developmental processes are known. Here we sought to identify transcriptional targets of the Wnt/β-catenin signaling pathway using a genome-wide approach. We selected putative targets using the criteria of reduced expression upon zygotic Wnt knockdown, β-catenin binding within 50kb of the gene, and expression in tissues that receive Wnt signaling. Using these criteria, we found 21 novel direct transcriptional targets of Wnt/β-catenin signaling during gastrulation and in addition have identified putative regulatory elements for further characterization in future studies.

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