Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Wnt/β-catenin in Xenopus laevis gastrulation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Xenopus laevis

PROVIDER: GSE77365 | GEO | 2016/04/25

SECONDARY ACCESSION(S): PRJNA310142

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Wnt/β-catenin in Xenopus laevis gastrulation

Project description:Wnt/β-catenin in Xenopus laevis gastrulation

| PRJNA310142 | ENA

Genome-wide identification of Wnt/β-catenin transcriptional targets during Xenopus gastrulation.

Project description:The canonical Wnt/β-catenin signaling pathway plays multiple roles during Xenopus gastrulation, including posteriorization of the neural plate, patterning of the mesoderm, and induction of the neural crest. Wnt signaling stabilizes β-catenin, which then activates target genes. However, few targets of this signaling pathway that mediate early developmental processes are known. Here we sought to identify transcriptional targets of the Wnt/β-catenin signaling pathway using a genome-wide approach. We selected putative targets using the criteria of reduced expression upon zygotic Wnt knockdown, β-catenin binding within 50kb of the gene, and expression in tissues that receive Wnt signaling. Using these criteria, we found 21 novel direct transcriptional targets of Wnt/β-catenin signaling during gastrulation and in addition have identified putative regulatory elements for further characterization in future studies.

| S-EPMC6288011 | biostudies-literature

Developmental gene expression of Xenopus laevis J strain

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-10-24 | E-GEOD-73431 | biostudies-arrayexpress

Transcriptome analysis of Wnt knockdown embryos reveals candidate canonical Wnt/β-catenin target genes during Xenopus laevis gastrulation

2016-04-25 | GSE77364 | GEO

Loss of Bap1 in Xenopus laevis embryos

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-09-26 | GSE126599 | GEO

Developmental gene expression of Xenopus laevis J strain

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-10-24 | GSE73431 | GEO

Spemann organizer transcriptome induction by early beta-catenin, Wnt, Nodal, and Siamois signals in Xenopus laevis.

Project description:The earliest event in Xenopus development is the dorsal accumulation of nuclear ?-catenin under the influence of cytoplasmic determinants displaced by fertilization. In this study, a genome-wide approach was used to examine transcription of the 43,673 genes annotated in the Xenopus laevis genome under a variety of conditions that inhibit or promote formation of the Spemann organizer signaling center. Loss of function of ?-catenin with antisense morpholinos reproducibly reduced the expression of 247 mRNAs at gastrula stage. Interestingly, only 123 ?-catenin targets were enriched on the dorsal side and defined an early dorsal ?-catenin gene signature. These genes included several previously unrecognized Spemann organizer components. Surprisingly, only 3 of these 123 genes overlapped with the late Wnt signature recently defined by two other groups using inhibition by Dkk1 mRNA or Wnt8 morpholinos, which indicates that the effects of ?-catenin/Wnt signaling in early development are exquisitely regulated by stage-dependent mechanisms. We analyzed transcriptome responses to a number of treatments in a total of 46 RNA-seq libraries. These treatments included, in addition to ?-catenin depletion, regenerating dorsal and ventral half-embryos, lithium chloride treatment, and the overexpression of Wnt8, Siamois, and Cerberus mRNAs. Only some of the early dorsal ?-catenin signature genes were activated at blastula whereas others required the induction of endomesoderm, as indicated by their inhibition by Cerberus overexpression. These comprehensive data provide a rich resource for analyzing how the dorsal and ventral regions of the embryo communicate with each other in a self-organizing vertebrate model embryo.

| S-EPMC5393196 | biostudies-literature

Characterization of regeneration initiating cells during Xenopus laevis tail regeneration

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-11-30 | GSE245320 | GEO

Global role of IGF2BP1 in controlling the expression of Wnt/β-catenin-regulated genes

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-09-19 | GSE237666 | GEO

Sp5 and Sp8 recruit b-catenin to the Tcf1-Lef1 enhanceosome to activate Wnt target gene transcription

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-04-01 | E-GEOD-73084 | biostudies-arrayexpress