Unknown,Transcriptomics,Genomics,Proteomics

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Sp5 and Sp8 recruit b-catenin to the Tcf1-Lef1 enhanceosome to activate Wnt target gene transcription


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Mark Kennedy 

PROVIDER: E-GEOD-73084 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription.

Kennedy Mark W MW   Chalamalasetty Ravindra B RB   Thomas Sara S   Garriock Robert J RJ   Jailwala Parthav P   Yamaguchi Terry P TP  

Proceedings of the National Academy of Sciences of the United States of America 20160311 13


The ancient, highly conserved, Wnt signaling pathway regulates cell fate in all metazoans. We have previously shown that combined null mutations of the specificity protein (Sp) 1/Klf-like zinc-finger transcription factors Sp5 and Sp8 (i.e., Sp5/8) result in an embryonic phenotype identical to that observed when core components of the Wnt/β-catenin pathway are mutated; however, their role in Wnt signal transduction is unknown. Here, we show in mouse embryos and differentiating embryonic stem cell  ...[more]

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