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Gene expression profiles of Lhcgr-deficient testes

ABSTRACT: Spermatogonial stem cells (SSCs) provide foundation for spermatogenesis by undergoing continuous self-renewal division. Previous studies have reported conflicting results on the role of the pituitary gland activity in SSC self-renewal. In this study, we analyzed the role of hormonal regulation of SSCs using Lhcgr (luteinizing hormone/choriogonadotropin receptor) knockout mice. Analysis of gene expression profiles showed that testes of Lhcgr-deficient mice exhibit significantly enhanced Wnt5a expression in Sertoli cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE77500 | GEO | 2016/07/15

SECONDARY ACCESSION(S): PRJNA310643

REPOSITORIES: GEO

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Gene expression profiles of Lhcgr-deficient testes

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