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Nodular lymphocyte predominant Hodgkin's lymphoma vs T cell/histiocyte rich B cell lymphoma

ABSTRACT: T-cell/histiocyte rich B cell lymphoma (THRBL) and nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) share some morphological characteristics, including a prominent stromal reaction, but display a markedly different prognosis. To investigate the difference between the stromal reactions of these lymphomas at the molecular level, we performed microarray expression profiling on a series of THRBL and NLPHL cases. Keywords: lymphoma, NLPHL, THRBL, stromal reaction

ORGANISM(S): Homo sapiens

PROVIDER: GSE7788 | GEO | 2009/11/27

SECONDARY ACCESSION(S): PRJNA99815

REPOSITORIES: GEO

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Transcription profiling to compare Nodular lymphocyte predominant Hodgkins lymphoma and T cell/histiocyte rich B cell lymphoma

Project description:T-cell/histiocyte rich B cell lymphoma (THRBL) and nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) share some morphological characteristics, including a prominent stromal reaction, but display a markedly different prognosis. To investigate the difference between the stromal reactions of these lymphomas at the molecular level, we performed microarray expression profiling on a series of THRBL and NLPHL cases. Experiment Overall Design: Microarray expression profiling was performed for 10 NLPHL and 10 THRBL cases. A pool of 5 reactive lymph nodes was included as a reference sample.

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