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ALS-causing mutations differentially affect PGC-1alpha expression and function in the brain vs. peripheral tissues

ABSTRACT: Amyotrophic later sclerosis is a motor neuron disease accompanied by metabolic changes. PGC (PPAR gamma coactivator)-1alpha is a master regulator of mitochondrial biogenesis and function and of critical importance for all metabolically active tissues. PGC-1alpha is a genetic modifier of ALS. We used microarray analysis to identify PGC-1alpha target genes in the brain.

ORGANISM(S): Mus musculus

PROVIDER: GSE77919 | GEO | 2016/11/10

SECONDARY ACCESSION(S): PRJNA312104

REPOSITORIES: GEO

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