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Expression data from adult mouse Nucleus Accumbens following prenatal infection

ABSTRACT: Prenatal exposure to infectious or inflammatory insults can increase the risk of neuropsychiatric disorders with neurodevelopmental components, including schizophrenia and autism. The molecular processes underlying this pathological association are only partially understood. Here, we implemented an unbiased genome-wide transcriptional profiling of the nucleus accumbens of mice exposed to prenatal infection on GD17 compared to control subjects in order to elucidate the long term molecular signature of late prenatal infection. We used microarray analysis to investigate the long lasting gene expression changes in a well-established mouse model that is based on maternal treatment with the viral mimic poly(I:C) during pregnancy

ORGANISM(S): Mus musculus

PROVIDER: GSE77971 | GEO | 2016/03/01

SECONDARY ACCESSION(S): PRJNA312224

REPOSITORIES: GEO

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Expression data from adult mouse Nucleus Accumbens following prenatal infection

Project description:Prenatal exposure to infectious or inflammatory insults can increase the risk of neuropsychiatric disorders with neurodevelopmental components, including schizophrenia and autism. The molecular processes underlying this pathological association are only partially understood. Here, we implemented an unbiased genome-wide transcriptional profiling of the nucleus accumbens of mice exposed to prenatal infection on GD17 compared to control subjects in order to elucidate the long term molecular signature of late prenatal infection. We used microarray analysis to investigate the long lasting gene expression changes in a well-established mouse model that is based on maternal treatment with the viral mimic poly(I:C) during pregnancy C57BL/6 mice were treated with the synthetic viral mimetic poly(I:C) (5 mg/kg, i.v.) or control (saline, i.v.) solution on gestation day 17. Offspring were subjected to cognitive and behavioral testing in adulthood, and then whole genome gene expression analysis with Affymetrix Microarray and subsequent q-PCR validation were performed on the nucleus accumbens.

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Expression data from adult mouse Prefrontal Cortex following prenatal infection

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Transcriptional alterations in Nucleus Accumbens somatostatin interneurons following exposure to cocaine

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Mus musculus

Project description:Expression data from adult mouse Nucleus Accumbens following prenatal infection

| PRJNA312224 | ENA