Transcriptomics

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Expression data from adult mouse Nucleus Accumbens following prenatal infection


ABSTRACT: Prenatal exposure to infectious or inflammatory insults can increase the risk of neuropsychiatric disorders with neurodevelopmental components, including schizophrenia and autism. The molecular processes underlying this pathological association are only partially understood. Here, we implemented an unbiased genome-wide transcriptional profiling of the nucleus accumbens of mice exposed to prenatal infection on GD17 compared to control subjects in order to elucidate the long term molecular signature of late prenatal infection. We used microarray analysis to investigate the long lasting gene expression changes in a well-established mouse model that is based on maternal treatment with the viral mimic poly(I:C) during pregnancy

ORGANISM(S): Mus musculus

PROVIDER: GSE77971 | GEO | 2016/03/01

SECONDARY ACCESSION(S): PRJNA312224

REPOSITORIES: GEO

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