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Effects of MBTD1 on gene expression

ABSTRACT: The NuA4/TIP60 acetyltransferase complex is a key regulator of genome expression and stability. Here, we identified MBTD1 as a new stable subunit of the complex and gleaned intriguing insights into TIP60’s function. Harboring a histone reader domain for H4K20me1/2, MBTD1 allows TIP60 to associate with specific gene promoters and to promote the repair of DNA double strand breaks by homologous recombination. Total RNA was analyzed on Illumina Human HT-12 V4.0 expression beadchip by McGill University and Genome Québec innovation Centre

ORGANISM(S): Homo sapiens

PROVIDER: GSE78024 | GEO | 2016/04/30

SECONDARY ACCESSION(S): PRJNA312379

REPOSITORIES: GEO

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