Genomics

Dataset Information

0

Chronic Alcohol Consumption Alters micro-RNA Radiation Responses in the Mouse Liver


ABSTRACT: Accumulating evidence suggests that lifestyle-related factors may influence radiation responses and the resulting cancer risks through epigenetic mechanisms, such as miRNA regulations. Chronic alcohol consumption is a major risk factor for various pathologies, including alcoholic liver disease. We have recently shown that consumption of Japanese sake promotes glutathione metabolism and anti-oxidative activities in the liver of irradiated C57BL/6 mice. Here we show that chronic alcohol consumption resulted in elevated ciculating levels of the inflammatory cytokine TNF-α and that it triggered specific miRNA regulations (such as the upregulation of the radio-resistant miR-210) that are susceptible to influence the resulting radiation effects in the mouse liver.

ORGANISM(S): Mus musculus Rattus norvegicus Homo sapiens

PROVIDER: GSE79186 | GEO | 2016/03/15

SECONDARY ACCESSION(S): PRJNA315124

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2016-03-15 | E-GEOD-79186 | biostudies-arrayexpress
2021-10-13 | GSE180700 | GEO
2013-04-01 | GSE42789 | GEO
2013-04-01 | E-GEOD-42789 | biostudies-arrayexpress
| PRJNA315124 | ENA
2024-07-22 | GSE248233 | GEO
2021-10-13 | GSE181520 | GEO
2024-08-05 | GSE273675 | GEO
2022-09-06 | GSE179398 | GEO
2019-05-15 | GSE81947 | GEO