Chronic Alcohol Consumption Alters micro-RNA Radiation Responses in the Mouse Liver
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ABSTRACT: Accumulating evidence suggests that lifestyle-related factors may influence radiation responses and the resulting cancer risks through epigenetic mechanisms, such as miRNA regulations. Chronic alcohol consumption is a major risk factor for various pathologies, including alcoholic liver disease. We have recently shown that consumption of Japanese sake promotes glutathione metabolism and anti-oxidative activities in the liver of irradiated C57BL/6 mice. Here we show that chronic alcohol consumption resulted in elevated ciculating levels of the inflammatory cytokine TNF-α and that it triggered specific miRNA regulations (such as the upregulation of the radio-resistant miR-210) that are susceptible to influence the resulting radiation effects in the mouse liver.
ORGANISM(S): Mus musculus Rattus norvegicus Homo sapiens
PROVIDER: GSE79186 | GEO | 2016/03/15
SECONDARY ACCESSION(S): PRJNA315124
REPOSITORIES: GEO
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