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Rebalancing gene haploinsufficiency in vivo by targeting chromatin

ABSTRACT: Here we show that the T-box transcription factor encoded by Tbx1 positively regulates monomethylation of histone 3 lysine 4 (H3K4me1) at a significant number of regions that it occupies throughout the genome, often located at the 3' end of target genes. Treatment of cells with Tranylcypromine (TCP), an inhibitor of histone demethylases, rescues the expression of approx. one third of the genes dysregulated by Tbx1 suppression and it rebalances H3K4me1 levels at many Tbx1 occupied sites. In addition, TCP treatment of mouse models of the 22q11.2DS ameliorates substantially the cardiovascular phenotype.

ORGANISM(S): Mus musculus

PROVIDER: GSE79941 | GEO | 2016/04/11

SECONDARY ACCESSION(S): PRJNA317495

REPOSITORIES: GEO

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Identification of H3 Lysine 4 Monomethylation Associated Proteins at Mammalian Enhancers

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2018-10-23 | PXD007942 | Pride

Rebalancing gene haploinsufficiency in vivo by targeting chromatin.

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Transcription factor Runx1 cooperates with MyoD and c-Jun to regulate the balance of myoblast proliferation/differentiation [ChIP-Seq Histone]

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Reduced dosage of β-catenin genetically rescues intracardiac anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome

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