Genomics

Dataset Information

0

Active and inactive enhancers co-operate to exert localized and long-range control of gene regulation [ChIP-seq]


ABSTRACT: We report that in developing B cells individual enhancers of Igk make up super-enhancer cluster where contacts between its components rely on all constituents. Reduction of interaction frequency in enhancer knock-out cells is associated with deminished transcriptional output of enhancers and Igk locus. Moreover, we find that Igk enhancer MiEk has an effect on levels of CBFb enrichment on Tcrb enhancer, Eb afffecting Tcrb recombination and T cell development.

ORGANISM(S): Mus musculus

PROVIDER: GSE80271 | GEO | 2016/05/26

SECONDARY ACCESSION(S): PRJNA318460

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2016-05-26 | GSE80270 | GEO
2016-05-26 | GSE80269 | GEO
2016-05-26 | GSE80268 | GEO
2016-05-26 | GSE80272 | GEO
| PRJNA318456 | ENA
2014-03-21 | E-GEOD-53896 | biostudies-arrayexpress
| S-EPMC4899175 | biostudies-literature
2014-03-21 | GSE53896 | GEO
2012-09-28 | E-GEOD-40684 | biostudies-arrayexpress
2018-10-22 | GSE115582 | GEO