Transcriptomics

Dataset Information

0

Secreted α-Klotho maintains tissue homeostasis by repressing NOS2-ZIP8-MMP13 catabolic axis


ABSTRACT: Progressive loss of tissue homeostasis hallmarks numerous age-related pathologies. By using parabiosic approaches in animal models, recent evidences demonstrate that age-regulated geronic factors such as GDF11 or CCL11 could widely control positively or negatively tissue homeostasis. Here we evaluated the impact of the first identified anti-geronic hormone a-Klotho on tissue homeostasis taken articular cartilage and osteoarthritis (OA) as studying models. We show that a-Klotho is secreted during an in vitro induced chondrogenesis of osteo-chondral stem cells. Expression of a-Klotho is reduced in both cartilage of OA patients compared to healthy donors and in cartilage of OA murine models. Gain and loss of function experiments followed by a genome-wide gene array analysis identified Nos2-Zip8-MMP13 catabolic axis as repressed in OA chondrocytes upon a-Klotho treatment. Accordingly, intra-articular delivery of secreted a-klotho delays cartilage loss of functions in experimental OA mouse models thus revealing a novel chondroprotective function for this anti-geronic hormone.

ORGANISM(S): Homo sapiens

PROVIDER: GSE80285 | GEO | 2018/01/21

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2017-07-24 | GSE85148 | GEO
2012-05-01 | E-GEOD-35546 | biostudies-arrayexpress
2012-05-02 | GSE35546 | GEO
2023-09-19 | GSE193175 | GEO
2024-01-19 | GSE253210 | GEO
2022-05-19 | PXD029116 | Pride
2021-04-17 | GSE171031 | GEO
2021-06-19 | GSE172500 | GEO
2023-04-19 | GSE220243 | GEO
2023-09-19 | GSE242732 | GEO