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Gene expression in healthy and gene deficient human naïve CD4+ T cells

ABSTRACT: Ascertain the effects of disease-causing gene mutations on the differentiation status of human naïve CD4+ T cells in the setting of primary immunodeficiencies. Thus, do CD4+ T cells isolated according to a naïve surface phenotype (ie CD4+CD45RA+CCR7+) from healthy donors exhibit a similar gene expression profile as phenotpyically-matched cells isolated from individuals with defined primary immunodeficiencies caused by specific monogenic mutations.

ORGANISM(S): Homo sapiens

PROVIDER: GSE81408 | GEO | 2016/06/29

SECONDARY ACCESSION(S): PRJNA321481

REPOSITORIES: GEO

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