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Bioenergetic Alterations in Colorectal Polyp and Cancer

ABSTRACT: Background: The change of cellular energy metabolism in colorectal carcinogenesis is poorly understood. It is widely accepted tht most, if not all, colorectal cancers (CRCs) arise from adenomatous polyps (APs). Our aim was to characterize the mitochondrial and bioenergetic alternations in the adenoma-carcinoma sequence. Results: Two glycolysis-related genes, aldolase B (ALDOB) and solute carrier family 16 member 4 (SLC16A4), were upregulated in polyps. This result was further confirmed by the real-time PCR analysis showing that the both ALDOB and SLC16A4 mRNA expressions were higher in the polyps with villous component compared with their adjacent normal mucosa.

ORGANISM(S): Homo sapiens

PROVIDER: GSE81804 | GEO | 2017/05/23

SECONDARY ACCESSION(S): PRJNA322588

REPOSITORIES: GEO

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