Transcriptomics

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A nested case-control study to investigate drivers for metastatic disease in breast cancer (QC substudy)


ABSTRACT: This is a quality control (QC) substudy of GSE48091. The QC substudy comprises gene-expression profiling of re-extracted tumor RNA for a subset of the tumours in the full study. As background, a population-based cohort study of metastatic breast cancer patients was first designed. Thereafter, a case-control study nested in the corresponding population-based cohort of primary breast cancer patients was designed by selecting distant metastasis-free controls to each case. Tumor RNA was extracted in the same order. All RNA was profiled on microarrays in randomized order. For quality control, RNA was also re-extracted (new tumor piece) in a randomized order for randomly selected cases-controls sets and profiled with the rest. Keywords: Expression profiling by array

ORGANISM(S): Homo sapiens

PROVIDER: GSE81954 | GEO | 2016/05/28

SECONDARY ACCESSION(S): PRJNA323489

REPOSITORIES: GEO

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