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PNET animal model: new insights

ABSTRACT: Recently, we described a new animal model of CNS primitive neuroectodermal tumors (CNS-PNET), which was generated by orthotopic transplantation of human Radial Glial (RG) cells into NOD-SCID mice’s brain sub- ventricular zone. In the current study we conducted comprehensive RNA-Seq analyses to gain some insights on the mechanisms underlying tumorigenesis in this mouse model of CNS-PNET. Here we show that the RNA-Seq profiles derived from these tumors cluster with those reported for patients’ PNETs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE82102 | GEO | 2017/06/12

SECONDARY ACCESSION(S): PRJNA324012

REPOSITORIES: GEO

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