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Cell type-specific regulation by intragenic CpG islands [WGBS]

ABSTRACT: We wanted to emphisize the role of intragenic CpG island in various cell differentiation. We especially examined the effect of DNA methyltransferase (DNMT) in the neural differentiation from mouse ES cell. Therefore, we performed the Whole-Genome Bisulfite Sequencing (WGBS) analysis of mouse ES cell, ESC-derived NPC, and also in DNMT double knockout (DKO) conditions. By utilizing these result, we confirmed the genes regulated by intragenic CpG island methylation have effect in NPC differentation.

ORGANISM(S): Mus musculus

PROVIDER: GSE82125 | GEO | 2017/12/30

REPOSITORIES: GEO

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