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Expression data from Tip110 transgenic mouse blastocyst-derived outgrowths

ABSTRACT: LONG SUMMARY: In this study, we aimed to characterize the function of Tip110 in embryonic development and in mESC survival and self-renewal using a Tip110+/- mouse model. Mating these mice produces wild-type, Tip110+/-, and Tip110-/- offspring. Tip110-/- offspring die early in mouse postimplantation development and mESCs cannot be derived from Tip110-/- blastocysts. Array analysis was performed to gain a better understanding of the underlying molecular mechanisms at play and to appreciate the biological role of Tip110 in embryo and ESC development. SHORT SUMMARY: We used microarray analysis to detail the global program of gene expression in Tip110-/- outgrowths compared to their wild-type counterparts to gain a better understanding of the biological role of the Tip110 protein in embryonic development and mESC survival and self-renewal.

ORGANISM(S): Mus musculus

PROVIDER: GSE83092 | GEO | 2017/04/26

SECONDARY ACCESSION(S): PRJNA324818

REPOSITORIES: GEO

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