AhR signaling reprograms newly activated CD4+ T cells promoting combinatorial expression of regulatory genes to suppress murine GVHD [72 hr]
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ABSTRACT: AhR activation during the first 3 days of an immune response is sufficient to reprogram CD4+ T cells, resulting in prevention of GVHD. To identify the early transciptional signature of AhR activation in CD4+ T cells, we performed analyses on mice treated with 2 different AhR ligands, TCDD and Cl-BBQ, in comparison with vehicle treated mice. Transcriptional responses were measured by global microarray analysis of donor alloresponding CD4+ T cells from spleen and lymph nodes.
ORGANISM(S): Mus musculus
PROVIDER: GSE83258 | GEO | 2016/09/01
SECONDARY ACCESSION(S): PRJNA325450
REPOSITORIES: GEO
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