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A computational systems approach for identification of synergistic specification genes facilitates lineage conversion to prostate tissue

ABSTRACT: We report that a computational systems approach can identify cell type specification genes that act synergistically, and demonstrate its application for reprogramming of fibroblasts to prostate tissue. We have employed three such master regulators (FOXA1, NKX3.1, and androgen receptor, AR) in a primed conversion strategy to generate prostate tissue from mouse fibroblasts, involving expression of pluripotency factors, tissue recombination with embryonic urogenital mesenchyme, and renal grafting.

ORGANISM(S): Mus musculus

PROVIDER: GSE83298 | GEO | 2017/04/21

SECONDARY ACCESSION(S): PRJNA325519

REPOSITORIES: GEO

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