Global analyses of RNA G-quadruplexes
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ABSTRACT: In vitro, some RNAs can form stable four-stranded structures known as G-quadruplexes. Although RNA G-quadruplex structures have been implicated in post-transcriptional gene regulation and diseases, direct evidence for quadruplex formation in cells has been lacking. Here, we developed a suite of methods that identify RNAs with quadruplex-forming ability and measure their folding state in living cells. Applying these methods to mammalian cell lines, the budding yeast S. cerevisiae and several bacteria, we characterized the folding landscapes of RNA G-quadruplexes in these species.
ORGANISM(S): Pseudomonas putida Mus musculus Escherichia coli Parasynechococcus marenigrum WH 8102 Saccharomyces cerevisiae Homo sapiens
PROVIDER: GSE83617 | GEO | 2016/09/24
SECONDARY ACCESSION(S): PRJNA326510
REPOSITORIES: GEO
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