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Blood transcriptional signature of HIV-associated tuberculous meningitis

ABSTRACT: Patients with HIV-associated TB meningitis (TBM) are known to experience systemic hyperinflammation, clinically known as immune reconstitution inflammatory syndrome (IRIS), following the commencement of antiretroviral therapy (ART). No prognostic markers or biomarkers have been identified to date and little is known about the mechanism mediating the hyperinflammation. We recruited a prospective cohort of 33 patients with HIV-associated TBM, 16 of whom developed TBM-IRIS, and performed transcriptomic profiling. Transcriptomic signatures that distinguish patients who would eventually develop IRIS were identified and indicated neutrophil and inflammasome activation as being the predominant mediator of TBM-IRIS pathogenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE83892 | GEO | 2017/06/10

SECONDARY ACCESSION(S): PRJNA327310

REPOSITORIES: GEO

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