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Genome-wide Identification of Neuronal Activity-regulated Genes in Drosophila

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE83976 | GEO | 2016/12/12

SECONDARY ACCESSION(S): PRJNA327584

REPOSITORIES: GEO

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Genome-wide identification of neuronal activity-regulated genes in <i>Drosophila</i>.

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Genome-wide Identification of Neuronal Activity-regulated Genes in Drosophila

Project description:Genome-wide Identification of Neuronal Activity-regulated Genes in Drosophila

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Identification of activity-induced Npas4-regulated genes in cortical inhibitory and excitatory neurons

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Project description:Experience-dependent gene transcription is required for nervous system development and function. However, the DNA regulatory elements that control this program of gene expression are not well defined. Here we characterize the enhancers that function across the genome to mediate activity-dependent transcription in mouse cortical neurons. We find that the subset of enhancers enriched for monomethylation of histone H3 Lys4 (H3K4me1) and binding of the transcriptional coactivator CREBBP (also called CBP) that shows increased acetylation of histone H3 Lys27 (H3K27ac) after membrane depolarization of cortical neurons functions to regulate activity-dependent transcription. A subset of these enhancers appears to require binding of FOS, which was previously thought to bind primarily to promoters. These findings suggest that FOS functions at enhancers to control activity-dependent gene programs that are critical for nervous system function and provide a resource of functional cis-regulatory elements that may give insight into the genetic variants that contribute to brain development and disease.

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