Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Reprogrammed neurons from adult dermal fibroblasts of patients with Huntington's disease

ABSTRACT: Reprogrammed neurons from adult dermal fibroblasts of patients with Huntington's disease

ORGANISM(S): Homo sapiens

PROVIDER: GSE84013 | GEO | 2017/12/11

SECONDARY ACCESSION(S): PRJNA327817

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

RNA-seq of human dermal fibroblasts reprogrammed into cardiomyocytes

Project description:bluk RNA-seq of human dermal fibroblasts reprogrammed into cardiomyocytes with the addition of siAJSZ

2021-09-01 | GSE183123 | GEO

Expression profile of dermal fibroblasts reprogrammed to a pluripotent state

Project description:Expression profile of dermal fibroblasts reprogrammed to a pluripotent state Keywords: cell-type comparison

2008-01-30 | GSE9865 | GEO

scATAC-seq of human dermal fibroblasts reprogrammed with MGT

Project description:scATAC-seq of human dermal fibroblasts reprogrammed with MGT

| PRJNA759228 | ENA

RNA-seq of human dermal fibroblasts reprogrammed into cardiomyocytes

Project description:RNA-seq of human dermal fibroblasts reprogrammed into cardiomyocytes

| PRJNA759230 | ENA

Transcription profiling of human fibroblasts, reprogrammed fibroblasts and human ES cells

Project description:Expression profile of dermal fibroblasts reprogrammed to a pluripotent state Experiment Overall Design: Compared fibroblasts to reprogrammed fibroblasts to human ES cells

2008-06-17 | E-GEOD-9865 | biostudies-arrayexpress

Proteomic analysis of mitochondria from Huntington's Disease patient iPSC-derived neurons

Project description:Huntington's disease is caused by an expanded CAG repeat in the huntingtin gene, yeilding a Huntingtin protein with an expanded polyglutamine tract. Patient-derived induced pluripotent stem cells (iPSCs) can help understand disease; however, defining pathological biomarkers in challanging. Here we used LC-MS/MS to determine differences in mitochondrial proteome between iPSC-derived neurons from healthy donors and Huntington's disease patients.

2023-02-10 | PXD037526 | Pride

Autophagy impairments in directly reprogrammed neurons in patients with idiopathic Parkinson’s disease

Project description:Protein degradation impairment is strongly suspected to play a role in idiopathic Parkinson’s disease (PD). However, current tools and models are lacking to study such disease associated phenotypes across the PD patient population. Here, we generate functional induced dopaminergic neurons (iDANs) directly reprogrammed from adult dermal fibroblasts of patients with PD to investigate intra-neuronal autophagy alterations.

2019-06-01 | GSE125239 | GEO

DNA Methylation profiling of human iNBSCs, iPSC-derived NBSCs and adult dermal fibroblasts

Project description:We describe a so far uncharacterized, embryonic and self-renewing Neural Plate Border Stem Cell (NBSC) population with the capacity to differentiate into central nervous and neural crest lineages. NBSCs can be obtained by neural transcription factor-mediated reprogramming (BRN2, SOX2, KLF4, and ZIC3) of human adult dermal fibroblasts and peripheral blood cells (induced Neural Plate Border Stem Cells, iNBSCs) or by directed differentiation from human induced pluripotent stem cells (NBSCs). Moreover, human (i)NBSCs share molecular and functional features with an endogenous NBSC population isolated from neural folds of E8.5 mouse embryos. Upon differentiation, iNBSCs give rise to either (1) radial glia-type stem cells, dopaminergic and serotonergic neurons, motoneurons, astrocytes, and oligodendrocytes or (2) cells from the neural crest lineage. Here we provide array-based methylation data of iNBSCs reprogrammed from adult dermal fibroblasts (ADF), iPSC-derived NBSCs and adult dermal fibroblasts. The data provided demonstrate robust changes in the methylation landscape after reprogramming of human adult dermal fibroblasts into iNBSCs.

2018-12-20 | E-MTAB-5808 | biostudies-arrayexpress

Hdac4 interactome in Huntington's Disease

Project description:Hdac4 has been found to modulate symptoms in Huntington's Disease (HD) mouse models through an uknown mechanism unrelated to any enzymatic activity. We investigated the protein-protein interactions to gain insight into the role of Hdac4 in HD.

2019-05-01 | PXD011845 | Pride

Progerin-induced transcriptional changes in Huntington's disease human pluripotent stem cells-derived neurons

Project description:Identification of transcriptional changes in Huntington's disease (HD) and normal (WT) human embryonic stem cells (hESC)- and induced pluripotent stem cells(iPSC)-derived striatal GABAergic neruons.

2020-01-01 | GSE111622 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data