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Gene expression of liver sinusoidal endothelial cells from an 8-week-old WT and ob/ob mouse

ABSTRACT: Obesity may promote myeloid cell accumulation in liver. Intravital liver tissue imaging revealed that the number of myeloid cells attached to sinusoidal wall significantly increased in ob/ob mice. To assess the pathophysiological roll of liver sinusoidal endothelial cells (LSEC) in obese livers, we performed microarray analysis in LSEC isolated from an 8-week-old wild-type and ob/ob mouse. Pathway analysis in microarray data shows genes related to cell adhesion, chemokine signaling and leukocyte transendothelial migration are upregulated in LSEC from ob/ob.

ORGANISM(S): Mus musculus

PROVIDER: GSE84019 | GEO | 2017/02/15

SECONDARY ACCESSION(S): PRJNA327826

REPOSITORIES: GEO

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