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Type-I-Interferons induce the decimation of antiviral B cells at the onset of chronic infection

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE84038 | GEO | 2016/09/19

SECONDARY ACCESSION(S): PRJNA327851

REPOSITORIES: GEO

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Type-I-Interferons induce the decimation of antiviral B cells at the onset of chronic infection [nanostring]

Project description:Abstract: Immune subversion represents a hallmark of persistent infection, but microbial suppression of B cell responses remains mechanistically ill-defined. Adoptive transfer experiments in a chronic viral infection model evidenced the rapid and profound decimation of B cells that responded to virus or to concomitantly administered protein. Decimation affected naïve and memory B cells and resulted from biased differentiation into short-lived antibody-secreting cells. It was driven by type I interferon (IFN-I) signaling to several cell types including dendritic cells, T cells and myeloid cells. Durable B cell responses were restored upon IFN-I receptor blockade or, partially, when depleting myeloid cells or key IFN-I-induced cytokines.

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Type-I-Interferons induce the decimation of antiviral B cells at the onset of chronic infection [RNA-seq]

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Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Type-I-Interferons induce the decimation of antiviral B cells at the onset of chronic infection

Project description:Type-I-Interferons induce the decimation of antiviral B cells at the onset of chronic infection

| PRJNA327851 | ENA

Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia