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Development of gene expression profiles for murine breast tumours treated with Sunitinib

ABSTRACT: In order to establish a profile of gene expression of tumours treated with sunitinib, 4T1 breast tumours were allowed to establish in Balb/C mice for 1 week. The mice were then treated with 40 mg/kg Sunitinib in PBS and 3.72% DMSO (treatemt group) or PBS-DMSO vehicle alone (no treatment group), daily for the period of the experiment, after which the tumours were resected homogenised and subjected to CD31 microbead separation of endothelial cells and bulk tissue, both of which were subjected to agilent microarray analysis. Treated tumours greater than 250 mm3 (by caliper measurement) after 8 days of treatment were considered resistant to treatment, those smaller than this were considered sensitive to sunitinib treatment.

ORGANISM(S): Mus musculus

PROVIDER: GSE84048 | GEO | 2016/07/06

SECONDARY ACCESSION(S): PRJNA327866

REPOSITORIES: GEO

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