Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Campylobacter concisus pathotypes induce distinct global responses in intestinal epithelial cells [UNSWCD]

ABSTRACT: We report the response of Caco-2 cells to infection by C. concisus strains or exposure to C. concisuszonula occludens toxin

ORGANISM(S): Homo sapiens

PROVIDER: GSE84337 | GEO | 2017/02/09

SECONDARY ACCESSION(S): PRJNA328933

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Campylobacter concisus pathotypes induce distinct global responses in intestinal epithelial cells [BAA]

Project description:We report the response of Caco-2 cells to infection by C. concisus strains or exposure to C. concisuszonula occludens toxin

2017-02-09 | GSE84335 | GEO

Campylobacter concisus pathotypes induce distinct global responses in intestinal epithelial cells [Toxin]

Project description:We report the response of Caco-2 cells to infection by C. concisus strains or exposure to C. concisuszonula occludens toxin

2017-02-09 | GSE84336 | GEO

Campylobacter concisus pathotypes induce distinct global responses in intestinal epithelial cells.

Project description:The epithelial response to the opportunistic pathogen Campylobacter concisus is poorly characterised. Here, we assessed the intestinal epithelial responses to two C. concisus strains with different virulence characteristics in Caco-2 cells using RNAseq, and validated a subset of the response using qPCR arrays. C. concisus strains induced distinct response patterns from intestinal epithelial cells, with the toxigenic strain inducing a significantly more amplified response. A range of cellular functions were significantly regulated in a strain-specific manner, including epithelial-to-mesenchymal transition (NOTCH and Hedgehog), cytoskeletal remodeling, tight junctions, inflammatory responses and autophagy. Pattern recognition receptors were regulated, including TLR3 and IFI16, suggesting that nucleic acid sensing was important for epithelial recognition of C. concisus. C. concisus zonula occludens toxin (ZOT) was expressed and purified, and the epithelial response to the toxin was analysed using RNAseq. ZOT upregulated PAR2 expression, as well as processes related to tight junctions and cytoskeletal remodeling. C. concisus ZOT also induced upregulation of TLR3, pro-inflammatory cytokines IL6, IL8 and chemokine CXCL16, as well as the executioner caspase CASP7. Here, we characterise distinct global epithelial responses to C. concisus strains, and the virulence factor ZOT, and provide novel information on mechanisms by which this bacterium may affect the host.

| S-EPMC5039708 | biostudies-literature

Campylobacter concisus pathotypes induce distinct global responses in intestinal epithelial cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-02-09 | GSE84338 | GEO

Campylobacter concisus pathotypes induce distinct global responses in intestinal epithelial cells

Project description:Campylobacter concisus pathotypes induce distinct global responses in intestinal epithelial cells

| PRJNA328931 | ENA

Investigation of Campylobacter concisus gastric epithelial pathogenicity

Project description:The gastric epithelial gene responses to Campylobacter concisus infection were investigated by comparative differential expression analysis

2023-12-27 | GSE242316 | GEO

Campylobacter concisus

Project description:Campylobacter concisus

| PRJNA1057606 | ENA

Campylobacter concisus

Project description:Campylobacter concisus overview

| PRJNA35917 | ENA

Campylobacter concisus

Project description:Campylobacter concisus Strain RCH 6

| PRJNA1057609 | ENA

Campylobacter concisus

Project description:Campylobacter concisus Genome sequencing and assembly