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Global transcriptome profiling of the 889PF mouse pleural fluid disseminating tumour cell-derived cell line, with or without Cd109 knockdown

ABSTRACT: In order to determine the role of Cd109 in regulating metastatic ability and identify Cd109-dependent transcriptonal targets in metastatic lung adenocarcinoma, we sequenced the mRNA from 3 mouse metastasis cell lines. Each of these cell lines (889PF-shGFP, 889PF-shCd109#1, and 889PF-shCd109#2) were derived from the same parental cell line 889PF. 889PF was derived from the pleural fluid of a Kras LSL G12D, p53 flox/flox 129S1/SvlmJ mouse model of metastatic lung adenocarcinoma. A comparison of shGFP and shCd109 cell lines reveals Cd109-dependent changes in the metastatic transcriptome.

ORGANISM(S): Mus musculus

PROVIDER: GSE84448 | GEO | 2017/02/06

SECONDARY ACCESSION(S): PRJNA329196

REPOSITORIES: GEO

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