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Glomerular Transcriptome Profiling Comparing DBA/2 and C57BL/6 mice

ABSTRACT: Comparing glomerular gene expression level between mice with different susceptibilities to diabetic nephropathy, DBA/2 (susceptible) and C57BL/6 (resistant) mice, respectively. The hypothesis is that differential expression of glomerular genes regulate susceptibility to diabetic nephropathy. The results show immune related genes. Thus, glomerular inflammation may increase susceptibility to diabetic nephropathy in mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE84663 | GEO | 2016/07/22

SECONDARY ACCESSION(S): PRJNA330785

REPOSITORIES: GEO

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Glomerular Transcriptome Profiling Comparing DBA/2 and C57BL/6 mice

Project description:Comparing glomerular gene expression level between mice with different susceptibilities to diabetic nephropathy, DBA/2 (susceptible) and C57BL/6 (resistant) mice, respectively. The hypothesis is that differential expression of glomerular genes regulate susceptibility to diabetic nephropathy. The results show immune related genes. Thus, glomerular inflammation may increase susceptibility to diabetic nephropathy in mice. RNA isolated from kidney glomeruli of DBA/2 and C57BL/6 mice, with or without 4 weeks diabetes induced by streptozotocin.

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