Transcriptomics

Dataset Information

0

RNAseq analysis to identify differential expressed genes in glomerular cDNA of diabetic DBA/2 mice with Esm1 over-expression


ABSTRACT: We aim to study the gene expression changes in glomeruli of DBA/2 mice with diabetic nephropathy with or without Esm-1 over-expression. We extract pure mice glomeruli, prepared total cDNA with random hexamers and performed RNAseq study to quantify transcriptome and identify differential expressed genes. With a sequencing depth of 20M, we detected 12934 genes in total. We found many interferon related genes shows differences between control and DM group, suggesting DBA/2 mice with diabetic nephropathy are driven by interferon related mechanisms. We found 41 genes show biologically meaningful differences between DM and Esm-1 + DM group, suggesting these genes are downstream targets of Esm-1 in mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE175449 | GEO | 2022/09/30

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2016-07-22 | E-GEOD-84663 | biostudies-arrayexpress
2016-07-22 | GSE84663 | GEO
2016-10-24 | E-GEOD-77717 | biostudies-arrayexpress
2021-09-10 | PXD017960 | Pride
2014-10-08 | GSE21390 | GEO
2004-04-01 | GSE1009 | GEO
2004-04-01 | E-GEOD-1009 | biostudies-arrayexpress
2018-07-31 | GSE96804 | GEO
2010-12-01 | E-GEOD-19251 | biostudies-arrayexpress
2021-07-17 | E-MTAB-9255 | biostudies-arrayexpress