Transcriptomics

Dataset Information

0

Gene expression profile of the germaniumu dioxide-related hearing loss cochlea in CBA mice


ABSTRACT: Various organ failure induced by chronic intake of GeO2 is one of the well known disease related to mitochondrial dysfunction. The 0.15% GeO2 treated CBA mice shows severe hearing loss in 4M. Here we analyzed cochlear gene expression of 6 months old CBA mice using microarrays treated with normal chow or that containing 0.15% GeO2 for four months. Auditory brainstem response (ABR) analysis confirmed that severe age-related hearing loss occured in GeO2 treated mice, whereas no hearing loss occured in normal chow treated mice. Comprehensive gene expression analysis identified genes correlated with GeO2-induced mithochodrial dysfunction genes and revealed that 28 genes encoding components of the mitochondrial respiratory chain were significantly down-regulated. These observations provide evidence that GeO2-induced hearing loss is associated with the down-regulation of genes involved in the mitochondrial respiratory chain complexes in the cochlea of CBA mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE84735 | GEO | 2016/07/22

SECONDARY ACCESSION(S): PRJNA330968

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2016-07-22 | E-GEOD-84735 | biostudies-arrayexpress
2008-06-14 | E-GEOD-6045 | biostudies-arrayexpress
2007-10-16 | GSE6045 | GEO
2013-03-12 | E-GEOD-45026 | biostudies-arrayexpress
2024-10-17 | PXD050415 | Pride
2013-08-06 | E-GEOD-49522 | biostudies-arrayexpress
2013-08-06 | GSE49522 | GEO
2013-08-06 | E-GEOD-49543 | biostudies-arrayexpress
| PRJNA330968 | ENA
2014-10-01 | E-GEOD-57782 | biostudies-arrayexpress