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Genome-wide DNA methylation profiling of prostate specimens from a clinical trial of genistein supplementation prior to prostatectomy.

ABSTRACT: To identify molecular effects of genistein on DNA methylation in prostate cancer, we compared DNA methylation profiles of genistein-treated tumors with placebo-treated samples. There were 156 probes with significantly increased methylation in placebo-treated cases versus normal tissues that were not significant between genistein-treated cases and normal tissues, suggesting that genistein may have had some demethylation effects. These 156 probes corresponded to at least 92 separate genes including ADCY4, ALOX12, HAAO, LRRC4, NEU1, RAPGEFL1, and WNT7B.These findings highlight the effects of genistein on global changes in DNA methylation in prostate cancer and its effects on molecular pathways involved in prostate tumorigenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE84749 | GEO | 2017/06/23

SECONDARY ACCESSION(S): PRJNA331019

REPOSITORIES: GEO

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Genome-wide expression profiling of prostate specimens from a clinical trial of genistein supplementation prior to prostatectomy.

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