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Genome-wide expression profiling of prostate specimens from a clinical trial of genistein supplementation prior to prostatectomy.

ABSTRACT: To identify molecular effects of genistein on mRNA levels in prostate cancer, we compared gene expression profiles of genistein-treated tumors with placebo-treated samples. There were 628 probes that reached nominally significant p-values. The genes that were differentially expressed between genistein and placebo samples were involved in angiogenesis, apoptosis, epithelial to mesenchymal transition, and tumor progression. Gene enrichment analysis suggested that PTEN and PDGF were activated, while MYC, beta-estradiol, glucocorticoid receptor NR3C1, and interferon-gamma were repressed in response to genistein treatment. These findings highlight the effects of genistein on global changes in gene expression in prostate cancer and its effects on molecular pathways involved in prostate tumorigenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE84748 | GEO | 2017/06/23

SECONDARY ACCESSION(S): PRJNA331020

REPOSITORIES: GEO

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Genome-wide DNA methylation profiling of prostate specimens from a clinical trial of genistein supplementation prior to prostatectomy.

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Project description:Prostate specimens from a clinical trial of genistein supplementation prior to prostatectomy

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Genistein Cooperates with the Histone Deacetylase Inhibitor Vorinostat to Induce Cell Death in Prostate Cancer Cells (methylation data)

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Genistein Cooperates with the Histone Deacetylase Inhibitor Vorinostat to Induce Cell Death in Prostate Cancer Cells (expression data)

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2012-12-01 | E-GEOD-35242 | biostudies-arrayexpress

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