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Next Generation Sequencing Comparison of Wild Type and Whsc1-/- Activated B-cell Transcriptomes

ABSTRACT: Whsc1 gene codes for a SET domain-containing H3K36 dimethylase, whose activity has been suggested, in ex vivo cell culture experiments, to control many aspects of DNA and RNA processing (replication, repair, transcription, etc). Its precise function in vivo is still unclear. Here, we use RNA-seq transcriptome analysis to study the changes in gene expression in the absence of Whsc1. Our results show that, in the experimental system used, loss of Whsc1 caused massive changes in genes affecting many fundamental cellular processes, from cell cycle to ribosome synthesis, DNA repair, replication, etc.

ORGANISM(S): Mus musculus

PROVIDER: GSE84878 | GEO | 2017/05/23

SECONDARY ACCESSION(S): PRJNA335426

REPOSITORIES: GEO

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