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Selective inhibition of Pin1 with a covalent small molecule targeting its catalytic domain

ABSTRACT: From a mechanism-based screening we have identified a novel Pin1 suicide inhibitor, KPT-6566, able to selectively inhibit Pin1 and target it for degradation. We have performed a transcriptiomic analysis comparing Pin1 specific RNA interference in MDA-MB 231 cells with KPT-6566 treatment to assess specificity of the KPT-6566 towards Pin1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE84909 | GEO | 2017/08/11

SECONDARY ACCESSION(S): PRJNA335619

REPOSITORIES: GEO

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Sulfopin, a covalent inhibitor of Pin1, blocks Myc-driven tumors in vivo

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