Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Pin1/mutant-p53 jointly controlled genes

ABSTRACT: To investigate the specific gene expression program by which mutant-p53 and Pin1 control invasion and metastasis in breast cancer cells, we compared the transcriptomic profile of control, mutant-p53 depleted or Pin1 depleted MDA-MB-231 cells. MDA-MB-231 cells were transfected twice with siRNA against Pin1, p53 or LacZ as a control. Transfections were performed by using Lifofectamine 2000 (Invitrogen) according to manufacture's procedure. Forty-eight hours after second transfection, samples were then processed for total RNA extraction and hybridization on Affymetrix microarrays. Three biological replicas (A, B, C) were used for each of the three conditions, for a total of 9 samples

ORGANISM(S): Homo sapiens

SUBMITTER: Silvano Piazza 

PROVIDER: E-GEOD-26262 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

TP53 missense mutations dramatically influence tumor progression, however, their mechanism of action is still poorly understood. Here we demonstrate the fundamental role of the prolyl isomerase Pin1 in mutant p53 oncogenic functions. Pin1 enhances tumorigenesis in a Li-Fraumeni mouse model and cooperates with mutant p53 in Ras-dependent transformation. In breast cancer cells, Pin1 promotes mutant p53 dependent inhibition of the antimetastatic factor p63 and induction of a mutant p53 transcriptio  ...[more]

Similar Datasets

Transcriptomics Pin1/mutant-p53 jointly controlled genes
2011-05-30 | GSE26262 | GEO
Transcriptomics Selective inhibition of Pin1 with a covalent small molecule targeting its catalytic domain
2017-08-11 | GSE84909 | GEO
Transcriptomics Impact of mutant p53 on TNF-induced gene expression
2014-10-27 | E-GEOD-53153 | biostudies-arrayexpress
Transcriptomics Pivotal role of HMGA1 gene signature in highly metastatic breast cancer
2013-12-10 | E-GEOD-35525 | biostudies-arrayexpress
Genomics,Multiomics E-GEOD-26262
2015-08-12 | E-GEOD-26262 | ExpressionAtlas
Transcriptomics Impact of mutant p53 on TNF-induced gene expression
2014-10-27 | GSE53153 | GEO
Transcriptomics shRNAi profiling of human MDA-MB-231 cells expressing anti-p53 (shp53) short-hairpin RNAs treated with TFGbeta or control
2009-04-11 | E-GEOD-14491 | biostudies-arrayexpress
Transcriptomics siRNA-mediated HNRPA2B1 knock-down in MDA-MB-231 cells
2012-02-28 | E-GEOD-35757 | biostudies-arrayexpress
Transcriptomics Expression data from Pin1 inhibitor ATRA and Pin1 knockdown
2015-04-12 | E-GEOD-63059 | biostudies-arrayexpress
Transcriptomics Effect of silencing of p53 on gene expression in MDA-MB 231 TNBC cell line. [sip53]
2023-10-06 | GSE214493 | GEO