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The effect of knockdown of SUN1/2 on LPS-primed macrophages

ABSTRACT: SUN1/2 are located on the inner nuclear envelope membrane, which comprise an N-terminal nucleoplasmic domain, a transmembrane segment and a C-terminal SUN domain. The nucleoplasmic domain of SUN1/2 interacts with lamina and/or chromatin binding proteins, while the SUN domain protrudes into the lumen of the nuclear envelope to interact with KASH proteins in a trimeric fashion. Defects in SUN proteins have been linked to human diseases including laminopathies, ataxia, progeria, lissencephaly, and cancer. To explore the role of SUN1/2 during macrophage activation, we explore microarray analysis of THP-1-derived macrophages after stable transfection of siVGLL4 for 48 h.

ORGANISM(S): Homo sapiens

PROVIDER: GSE85022 | GEO | 2019/09/01

REPOSITORIES: GEO

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Depletion of Sun1/2 Induces Heterochromatin Accrual in MSCs

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Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA

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