Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ya-Hui Chi
PROVIDER: E-GEOD-12867 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA.
Chi Ya-Hui YH Cheng Lily I LI Myers Tim T Ward Jerrold M JM Williams Elizabeth E Su Qin Q Faucette Larry L Wang Jing-Ya JY Jeang Kuan-Teh KT
Development (Cambridge, England) 20090211 6
The inner nuclear envelope (NE) proteins interact with the nuclear lamina and participate in the architectural compartmentalization of chromosomes. The association of NE proteins with DNA contributes to the spatial rearrangement of chromosomes and their gene expression. Sun1 is an inner nuclear membrane (INM) protein that locates to telomeres and anchors chromosome movement in the prophase of meiosis. Here, we have created Sun1-/- mice and have found that these mice are born and grow normally bu ...[more]
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