Generation of intestinal progenitor cells from mouse fibroblasts

ABSTRACT: We show direct conversion of mouse fibroblasts to cells that closely resemble intestinal stem cells (ISCs), through the state of fetal-type progenitor cells, called FIPCs. The induced ISCs (iISCs) exhibit self-renewal capacity and intestinal multi-lineage differentiation potential. Upon transplantation, iFIPCs and iISCs reconstitute colonic and intestinal epithelia, respectively.

ORGANISM(S): Mus musculus

PROVIDER: GSE85232 | GEO | 2017/09/22

SECONDARY ACCESSION(S): PRJNA337910

REPOSITORIES: GEO