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TCF1 is required for the generation of TCF1highTim3low virus-specific CD8 T cells

ABSTRACT: T-cell exhaustion is frequently observed during chronic viral infection and cancer. How exhausted T cells persist in the presence of immunosuppression is unclear. Here, we showed that virus-specific CD8 T cells differentiate into Tfh-like TCF1highTim3lowBlimp1low progenitors before the chronic phase of viral infection, which persist better than and can give rise to more terminal TCF1lowTim3highBlimp1high cells. Differentiation of TCF1high cells is driven by master regulator TCF1. Cell-intrinsic TCF1 deficiency led to sharp contraction and eventual deletion of virus-specific CD4 and CD8 T cells and uncontrolled viremia

ORGANISM(S): Mus musculus

PROVIDER: GSE85367 | GEO | 2016/12/22

SECONDARY ACCESSION(S): PRJNA338284

REPOSITORIES: GEO

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