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Catch-and-release of cytokines converts transient exposure into long-term inflammatory responses

ABSTRACT: We report that after cancer cells are exposed to a transient pulse (5h) of the pro-inflammatory cytokine IFNγ, they continue up-regulating genes in the antigen presentation pathway for days after abrogation of the original signal. We discovered that a new mechanism of cell-to-cell communication, cytokine catch-and-release, explains this surprising result.

ORGANISM(S): Mus musculus

PROVIDER: GSE85535 | GEO | 2017/04/18

SECONDARY ACCESSION(S): PRJNA338754

REPOSITORIES: GEO

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