Transcriptomics

Dataset Information

0

Analysing gene expression signatures of whole thymospheres derived from adult (A) or embryonic day 14.5 (E) mouse thymus


ABSTRACT: Thymosphere-forming cells undergo phenotypic changes during ontogeny that are likely to reflect changes in gene expression patterns within thymospheres. We therefore isolated total RNA from pooled thymospheres derived from E14.5 or adult thymic digests and analysed their transcriptome by whole-genome microarrays. Several thymic epithelial markers including those associated with progenitor cells were differentially expressed in embryonic vs adult thymospheres. Gene ontology analysis revealed that pathways related to major key biological processes displayed changes between these two stages of ontogeny. We found significant differences in pathways involved in cell proliferation, development and differentiation, cell metabolism, regulation of transcription and regulation of DNA repair. Most interestingly, we observed significant enrichment of gene expression in several signalling pathways.

ORGANISM(S): Mus musculus

PROVIDER: GSE86267 | GEO | 2016/09/14

SECONDARY ACCESSION(S): PRJNA341331

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2013-06-24 | E-MTAB-1452 | biostudies-arrayexpress
2021-10-02 | E-MTAB-5362 | biostudies-arrayexpress
2021-05-29 | GSE154166 | GEO
2019-11-20 | GSE138494 | GEO
2016-03-03 | E-GEOD-76974 | biostudies-arrayexpress
2023-08-31 | GSE240784 | GEO
2018-02-01 | GSE106981 | GEO
2010-01-29 | GSE13632 | GEO
2016-03-03 | GSE76974 | GEO
2012-02-17 | GSE35107 | GEO