Foxo3 drives pathogenic Th1 differentiation
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ABSTRACT: We showed that the transcription factor Foxo3 played a specific role in the polarization of CD4+ T cells towards pathogenic Th1 cells producing both interferon-γ (IFN-γ) and granulocyte monocyte colony stimulating factor (GM-CSF). To understand the molecular mechanisms whereby Foxo3 controls CD4+ T cell differentiation, unbiased analysis of genes differentially expressed in Foxo3-deficient vs. Foxo3-sufficient CD4+ T cells was achieved using both resting and activated CD4+ T cells obtained following 12 or 24 hours of stimulation with anti-CD3 mAbs.
ORGANISM(S): Mus musculus
PROVIDER: GSE86287 | GEO | 2016/09/01
SECONDARY ACCESSION(S): PRJNA341366
REPOSITORIES: GEO
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