Transcriptomics

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Intestinal SIRT1 in the regulation of intestinal tissue homeostasis


ABSTRACT: The goal of this project is to investigate the role of SIRT1, the most conserved mammalian NAD+-dependent protein deacetylase, in the regulation of intestinal tissue integrity. Using a mouse model with specific deletion of SIRT1 in intestinal epithelium (SIRT1 iKO mice), we recently discovered that deletion of intestinal SIRT1 in mice age-dependently elicits NF-κB signaling and other stress response pathways, activates intestinal secretory cells, enhances spontaneous inflammation, and alters commensal gut microbial composition. To understand the molecular mechanisms underlying these age-dependent phenotypes, we examined the transcriptomes of young (6-8 week old) and aged (24-month old) ilea and aged colons from Flox controls and SIRT1 iKO mice by microarray analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE86475 | GEO | 2017/05/30

SECONDARY ACCESSION(S): PRJNA342030

REPOSITORIES: GEO

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