Transcriptomics

Dataset Information

0

Panton-Valentine Leukocidin Does Not Impact Virulence of Community-associated MRSA


ABSTRACT: Panton-valentine leukocidin (PVL) has been linked to worldwide emergence of community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) -- its role in virulence in unclear. Here we show that PVL had no effect on global gene expression of prominent CA-MRSA strains nor did it affect bacterial clearance from lungs, spleen and kidneys in a highly discriminatory rabbit bacteremia model. These findings negate a large body of epidemiological research that implicated PVL in CA-MRSA virulence. Keywords: mutant vs wild type in 2 different growth phases grown in 2 different medias

ORGANISM(S): Rickettsia rickettsii Staphylococcus epidermidis RP62A Yersinia pestis Chlamydia trachomatis Coxiella burnetii RSA 493 Granulibacter bethesdensis Staphylococcus epidermidis ATCC 12228 Coxiella burnetii Chlamydia muridarum Chlamydia trachomatis D/UW-3/CX Staphylococcus haemolyticus JCSC1435 Borreliella burgdorferi B31 Streptococcus pyogenes Staphylococcus aureus Chlamydia pneumoniae AR39 Staphylococcus aureus subsp. aureus MW2 Borreliella burgdorferi Chlamydia caviae GPIC

PROVIDER: GSE8677 | GEO | 2008/09/12

SECONDARY ACCESSION(S): PRJNA101893

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2010-06-19 | E-GEOD-8677 | biostudies-arrayexpress
2012-05-31 | E-MEXP-3627 | biostudies-arrayexpress
2007-02-13 | GSE6985 | GEO
2012-09-06 | GSE33939 | GEO
2012-09-06 | E-GEOD-33939 | biostudies-arrayexpress
2009-12-31 | GSE14394 | GEO
2023-11-23 | PXD025702 | Pride
| PRJNA101893 | ENA
2011-03-29 | GSE18793 | GEO
2011-12-31 | E-GEOD-26585 | biostudies-arrayexpress